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Injectable semaglutide (Ozempic) delivers slightly better blood sugar control and weight loss due to more efficient drug absorption, while oral semaglutide (Rybelsus) avoids injections entirely

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10.1016/j.cmet.2008.11.002 79 RenX.FerreiraJ

In the context of plaque biology, fibrous-plaque expansion is a favorable structural change: dense, collagen-rich fibrous tissue forms a thicker cap that insulates the thrombogenic lipid core from circulating coagulation factors

However, Semaglutide's robust GLP-1 receptor activation often overcomes these hormonal challenges, with clinical studies showing sustained weight reduction even in patients with elevated stress hormones, ultimately delivering meaningful results when combined with lifestyle modifications