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Improved mood : B12 is also involved in the production of neurotransmitters that affect mood, such as serotonin and dopamine

Berberine was found to downregulate CSC-like features, inhibit GLI1 signaling-induced EMT, and control ovarian cancer cell metastasis (164)

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It got to the point, he says, that it was hindering his day-to-day life and he started to feel "really down"