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2ml weekly is at the high end of standard protocols and appropriate for loading phases, concurrent GLP-1 therapy, or documented hepatic steatosis

Other treatment options could be better choices

8 Challenges and Considerations in Multi-Agonist Therapy Despite their advantages, GLP-1-based therapies face several challenges in adolescent populations: Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, and constipation are common adverse events, especially during dose escalation

By bypassing the liver, sublingual semaglutide may deliver a more consistent and reliable dose

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