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[28] [29] Patients should maintain open communication with their healthcare team, report new symptoms promptly, and never discontinue prescribed medications without medical guidance

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STEP trial patients on SSRIs lost slightly more weight on average than those not taking antidepressants

Cost-effectiveness studies conducted in the UK, Portugal, Canada, and the United States consistently concluded that semaglutide is cost-effective relative to lifestyle management and other pharmacotherapies, including liraglutide (32), who conducted a decision analysis in the Egyptian setting and reported semaglutide 2.4 mg as a cost-effective and clinically superior alternative to liraglutide 3.0 mg for achieving significant weight loss