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Kara, et al., 'Effects of Retatrutide on Learning and Memory in Streptozotocin-Induced Diabetic Rats', bioRxiv , Jan

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This includes individuals with: Diagnosed MASLD or MASH, where GLP-1 therapy may offer therapeutic benefits but requires monitoring Chronic viral hepatitis (hepatitis B or C), particularly if transaminases are elevated Autoimmune hepatitis or other inflammatory liver conditions Cirrhosis or advanced fibrosis, where specialist consultation may be appropriate despite generally not requiring dose adjustment History of drug-induced liver injury from other agents For these patients, baseline comprehensive liver assessmentincluding liver enzymes, synthetic function tests (albumin, INR), and potentially imaging or non-invasive fibrosis markers (such as FIB-4 or ELF)helps establish a reference point for monitoring treatment effects

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In the prefrontal cortex, Doxorubicin and Cyclophosphamide treatment caused a significant decrease in BDNF expression when compared to the control group by 1.54 folds

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This approach demonstrated high feasibility for early in vivo diagnosis of ACI/AKI, detecting these conditions at least 24 and 48 hours earlier than standard clinical assays for ACI and AKI, respectively

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