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The risk was more than doubled in trials using GLP-1 medications for weight loss
Additionally, microdosing is unlikely to deliver the clinically proven weight loss associated with standard dosing
Due to species differences, dulaglutide (a human GLP-1 variant fused with a human IgG4 variant) showed a longer t 1/2 in humans than in monkeys (120 h versus 51.6 3.2 h, respectively) and further research will be required to determine whether Exendin-4-Fc also has a longer t 1/2 in humans
At least one approved GLP-1 manufacturer (Eli Lilly) has filed a complaint with the ITC against various online pharmacies selling compounded drugs containing tirzepatide
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