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A post hoc analysis from the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial examined the effects of liraglutide vs placebo in subjects aged 75 years (n = 836) and in those aged 6074 years (n = 6183) [34]

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CENTRAL EFFECTS MC4R Hypothalamic MC4R The MC4R receptor is expressed in the paraventricular (PVN) and arcuate nuclei of the hypothalamus, which are integrators of sexual motivation, feeding control, and autonomic regulation

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