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The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013

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It was reclassified from FDA Category 2 (restricted) back to Category 1 (compoundable) following HHS Secretary RFK Jr.s announcement on February 27, 2026

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Think of Ceramides as your skins bodyguards, protecting it from irritants, pollutants, and environmental stressors