They were only permitted during shortages, and since the FDA has ended that allowance , they are no longer considered legally permitted
I just mentioned a post-diagnosis weight gain of over 10% is associated with worse outcomes, so if that 5% weight loss can be combined with additional lifestyle factors, that gets towards attenuating that weight gain that patients may see and can be meaningful in terms of patients quality of life, how they tolerate their endocrine therapies, how they feel, and their body image
While daily use before routine training is not necessarily recommended, strategic supplementation before high-load sessions, time trials, or competitions may help reduce perceived exertion and optimize fat oxidation
In some cases, using a simple saline nasal spray can help moisturize the nasal passages and wash away irritants
In head-to-head clinical trials (SURMOUNT-5), tirzepatide produced greater average weight loss (20.2% vs 13.7%)