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As a 2022 report noted, "obesity remains the most important risk factor for the incidence and progression of osteoarthritis." According to Bliddal, the researchers launched the study to answer this question: "Would a highly effective anti-obesity medication improve KOA to a clinically meaningful degree?" Other studies had tackled the question with inconsistent results, he said

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ACs influence immune responses by modulating inflammatory cytokine production [16], while mitochondrial dysfunction exacerbates oxidative stress and inflammatory signaling [17]

David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, et al

The BUD is calculated from the date of compounding, not the date of delivery or first use