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Figure 5 Rheumatoid arthritis RA is a relatively systemic common autoimmune disease with manifestations that include irreversible peripheral joint destruction and functional loss (100)
Beside this, Spirulina also enhanced Toll like receptor (TLR)-2 and 4 mediated production of IL-12 from peripheral blood mononuclear cells, thus indicating Spirulina first activates monocytes and macrophages to produce cytokines that stimulate NK cells (37)
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Smith EM, Pang H, Cirrincione C, et al
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