Week 25 to 52: Long-term phase
blending with lubricant and glidant in a Turbula mixer
These medications act primarily on the GLP-1 or dual GLP-1 and GIP receptors, which influence hunger, satiety, and glucose control
In addition to GLP-1R agonists, orally administrated DPP4-inhibitors, e.g., sitagliptin and saxagliptin , which are known to potentiate the effect of endogenous GLP-1 by inhibiting its degradation, have also been clinically studied as protective agents against retinopathy (Svenningsson et al., 2016) in T2D patients, although DPP4-inhibitors cannot cross the blood-brain barrier (Mousa and Ayoub, 2019)
Hyponatraemia : SSRIs like fluoxetine can cause hyponatraemia (low sodium levels), particularly in older adults or those taking diuretics