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a reduced form of GSH dimerizes to its oxidized form, glutathione disulfide GSSG(Owen & Butterfield, 2010), such that the ratio of GSH to GSSG gives information about the cells healthy response to OS
Within this context, it is not surprising that a great deal of inhibitors and pro-drugs targeting GSTs have been synthesized and tested so far, with new scaffolds or analogues being reported every year
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