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We included 26 records regarding the safety of GLP-1 agonists during pregnancy and/or lactation ( Supplement 2 , 3 ), and 16 records regarding the safety of SGLT2 inhibitors during pregnancy and/or lactation ( Supplement 2 , 3 )

Skin color is largely determined by genetics and melanin production

[1] [4] Additional safety considerations include the risk of gallbladder disease (cholelithiasis, cholecystitis) and the potential for dehydration and acute kidney injury with severe gastrointestinal side effects

Affuso, O

Someone with a genetic predisposition favoring lower appetite sensitivity may achieve sustained weight loss through diet and exercise alone