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Lancet 386, 147283 (2015)
Consider protein supplementation if dietary protein targets cannot be met consistently
Finally, GH was shown to increase the renal synthesis of the antiaging hormone Klotho in healthy subjects and patients with CKD, indicating that GH treatment may have beneficial effects on the cardiovascular system
GH is responsible for many aspects of growth and development and plays a key role in metabolism
Future directions and research priorities Future research should prioritize well-controlled human intervention studies integrating GLP-1based pharmacotherapy with defined postbiotic preparations, with explicit assessment of body composition, lean mass preservation, and post-discontinuation weight trajectories
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