demonstrated in 2001 that AOD-9604 stimulates lipolysis in adipose tissue without activating the growth hormone receptor, a finding that separated its fat-metabolizing action from GH-related proliferative risks [1]
During this process, nitro groups are added to two locations on the protein, Y198 and Y250
doi:10.1177/0960327113506723 Joshi EM, Heasley BH, Macdonald TL (2009) 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton
HG also induced epithelial-mesenchymal transition (EMT) and upregulated fibrosis-related genes, suggesting that HG-induced EMT contributes to subretinal fibrosis, the end-stage of eye diseases, including proliferative DR
For single-dose, single-use only