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As a general clinical principle: Retest HbA1c no sooner than three months after commencing B12 replacement therapy, and ideally once haematological recovery has been confirmed Confirm haematological recovery normalisation of MCV and haemoglobin before interpreting the repeat HbA1c as reliable Use interim glucose monitoring such as fasting plasma glucose, OGTT, or self-monitored blood glucose (SMBG) to assess glycaemic control during the treatment period

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This is especially important for individuals taking diabetes medications, as acute caffeine intake may affect diabetes and make high blood sugar harder to control to maintain stable glucose levels

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Third-party testing provides independent verification of compound quality that researchers need to maintain experimental validity