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In addition, the TGF- pathway plays a vital role in platinum resistance via canonical downstream EMT-related molecules [141]

[2] Commercially it is made using one of a number of types of bacteria

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For instance, it has been shown that after an experimental psychologic stress, the evoked cortisol response in fatigued breast cancer survivors is much smaller than that in nonfatigued ones, pointing to the involvement of the HPA axis in cancer-related fatigue (286)

However, theres an important caveat: most of the data comes from animal research, not human clinical trials