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Because the stomach is significantly smaller after surgery, lower doses may be needed to avoid unwanted side effects or excessive weight loss

NICE CG189 recommends bariatric surgery for adults with a BMI 40 kg/m, or 35 kg/m with a significant obesity-related comorbidity, after non-surgical measures have failed

For this reason, the most consistent connections between GLP-1 biology and aging emerge in the next tier of the hallmarks of aging framework, Antagonistic

Long-term management requires a systematic approach rather than treating each reaction as an isolated event