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These molecules recruit the speck-like protein, resulting in caspase-1 activation, subsequent GSDMD cleavage, and interleukins interleukin (IL)-18 and IL-1 maturation (159, 163)

[PMID: 6465684] PubMed record related to this compound for laboratory literature review

Novel p53 Mutant Mouse Model Recapitulates the Biology of Human Therapy-Related Myeloid Neoplasms

Ferroptotic cancer cells also release danger-associated lipids and iron intermediates that recruit and activate macrophages, creating positive or negative regulatory loops ( 5 Iron homeostasis and immune regulation in the tumor microenvironment 5.1 Impact of macrophage polarization states on iron metabolism During early tumorigenesis, M1-type tumor-associated macrophages (TAMs) facilitate cellular iron uptake via transferrin receptor 1 (TfR1/CD71), while ferritin (FT) restricts iron efflux, resulting in iron sequestration