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For comparison of the mechanisms, the reaction catalyzed by the bacterial ketosteroid isomerase entails stabilization of the dienolate by a Tyr and an Asp residue interacting with the O 3 atom, whereas a single Asp residue serves the acid/base function exerted by the glutathione thiolate/Tyr9 pair in GST A3-3 (Pollack, 2004)
Her endocrinologist reviewed her remarkable progress: A1C dropped from 8.2% to 5.9%, blood pressure normalized off medications, and 40-pound weight loss eliminated joint pain
Nutrients 13:196
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