15 mg weekly produces ~23% 5 mg every 2 weeks retains ~70% of weekly efficacy Switching from 5 mg weekly to 10 mg every 2 weeks retains 95% of efficacy at 50% of cost non-linear and saturating
Risk Stratification & Contraindications Patient safety must guide the initiation of GLP-1 therapy, and therapy should be withheld if contraindications are present: Absolute Contraindications: Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Cautionary History: Previous pancreatitis or gastroparesis 5
They all started as diabetes drugs, but they caused a lot of weight loss
Then in 2019, a meta-analysis study tried to clarify the OS marker profile in ALS patients: the authors demonstrated that 8-OHdG and MDA were significantly increased in the peripheral blood of ALS patients when compared with control subjects, while GSH levels were significantly reduced
Ali also noted that, if it can be demonstrated that semaglutide improves fracture risk independent of weight loss, it would provide another clear indication for its prescription. However, he said, I do not believe that conclusion can be made based on this specific study