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One major way the reproductive system is distorted is by disrupting the endocrine system [16, 17], enhancing oxidative, apoptotic, and inflammatory processes [18, 19], and by impairing spermatogenesis [18, 20]
It does not force a biochemical shutdown
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Oxidative stress raises intracellular free Ca 2+ levels, which may have deleterious consequences
Thus, studies suggest that PQQ may be beneficial in insulin resistance and type 2 diabetes ( in vivo and in vitro , regulated by the NLRP3 inflammasome ( PQQ showed protective effects on lipotoxicity and inflammation caused by maternal obesity, and intervention on the risk of NAFLD (Zhou et al., 2021)
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