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The neuroprotective effect of GLP-1R agonists is that it can either directly/locally cause neuroprotection by acting on neuronal tissue or indirectly/systemically cause neuroprotection by improving glycemic control and treating existing insulin resistance (Figure 3) (Fiory et al., 2019
MC4R agonism reduces ghrelin signalling and delays the gastric emptying rate, creating early satiety that lasts 48 hours
Melanotan-2 was replaced by a nasally administered molecule (PT-141, Palatin Technologies), which was studied in erectile dysfunction
Experimental data shows that at the same concentration, the biological activity of IGF-1 LR3 is 3-5 times that of natural IGF-1
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