GLP-1R agonists increase microvascular recruitment and blood flow in skeletal and cardiac muscle, even in the presence of insulin resistance, which may improve tissue oxygenation and metabolic responses [161]
It is recommended that you start with the lowest concentration and then increase the amount gradually
Others may need additional medical support, especially if hunger, cravings, blood sugar changes, or weight regain return quickly
Investigations may include thyroid function tests (TSH, free T4), full blood count, ferritin, vitamin B12 and folate levels to exclude hypothyroidism or anaemia, both of which can cause cold intolerance and may require specific treatment
How can I obtain a prescription for Tirzepatide in Apple Valley, CA