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Metabolomics-based research may further reveal valuable biomarkers for therapy monitoring, as the reprogramming of ammonium metabolism in prostate cancer generates a range of intermediate metabolites, such as polyamines, citrate, and various amino acids, as well as key metabolic enzymes, which hold promise as indicators of therapeutic response (284)

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Female mice exhibited notable gains in spontaneous alternation scores at weeks 8 and 12, while males showed earlier improvement beginning at week 4

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