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2018(131):55491 doi: 10.3791/55491 13

It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength

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Multiple clinical trials and controlled studies have demonstrated: Statistically significant improvements in skin firmness and elasticity with consistent use Reduction in fine lines and wrinkle depth over 3-6 months of application Improved skin density, moisture retention, and surface texture Reduction in photodamage and hyperpigmentation Tightening of loose skin documented in both topical and injectable applications Citation: Leyden JJ et al

Whether that promise holds up in practice is exactly what this review examines