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The SELECT trial, published in 2024, showed that semaglutide reduced major adverse cardiovascular events (MACE: heart attack, stroke, cardiovascular death) by 20% in individuals with obesity, even independent of weight loss magnitude. Why
This overall reduction in glucose utilization detected by 18F-fluorodeoxyglucose-PET (positron emission tomography) imaging persists in the context of chronic cognitive impairment after TBI [35]
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In addition, although the fasting glucose levels showed no difference, the HbA 1c increased significantly at 4 weeks and prolonged to 16 weeks (Figure 1D), together with increased insulin, C-peptide, and homeostatic model assessment for insulin resistance (HOMA-ir) (Figures 1E1G)
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