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[6] The only notable exception is that biotin should not be used in anyone with a known hypersensitivity or allergy to biotin or any ingredients in the injection formulation (such as the diluent or preservatives), though such cases are exceedingly rare

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Senescent Chondrocyte Removal & Chondrogenic Potential Restoration (PMC, 2021) FOXO4-DRI Removes Replication-Stress Senescent Chondrocytes in ACI Research Model A study published in PMC investigated FOXO4-DRI in the context of autologous chondrocyte implantation (ACI) a procedure in which in vitro chondrocyte expansion generates a senescent cell burden that adversely affects cartilage formation quality and quantity