Zhang D, Ma M, Liu Y
In addition to maintaining hepatic metabolic homeostasis, AMPK activation has been reported to promote mitochondrial function and suppress endoplasmic reticulum (ER) stress 22

To support healthy glutathione levels: Ensure adequate protein intake with sulfur-rich foods (eggs, poultry, fish, cruciferous vegetables) Meet choline requirements (only 11% of pregnant women achieve this) Supplement with vitamins C and E to support glutathione recycling Ensure adequate B vitamins (B6, B12, folate) for methylation support Minimize environmental exposures (chlorinated water, VOCs, formaldehyde) Consider N-acetylcysteine (NAC) supplementation under healthcare provider guidance Work with a functional medicine practitioner to optimize metabolic health before and during pregnancy When considering acetaminophen: Discuss your individual risk factors with your healthcare provider Consider whether you have PCOS, conceived via IVF, have gestational blood sugar issues, gallbladder issues, or choline deficiency Understand that "safe" doses assume normal detoxification capacity If you have compromised glutathione status, even therapeutic doses may pose risk The danger isn't acetaminophen as a moleculeit's the toxic metabolite created when vulnerable populations with impaired detoxification capacity try to process it

That is not trivial
I think ultimately, at the end of the day, we all just want to feel good and feel good about ourselves. She added, If you're not hurting anybody, and you're not hurting yourself, you should do what you feel is right for your body or your mind or whatever. She has always struggled with her weight