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19% after 16 hr, n=90)

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

Patients typically regained approximately two thirds of the weight they had lost within a year of stopping using the medication (1,3)

doi: 10.1111/dom.14831

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