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Its authors found that use of semaglutide reduced: deaths from causes related to cardiovascular disease by 17% hospitalizations for heart failure by 76% non-fatal myocardial infarction (heart attack) by 24% the need for coronary revascularization by 24% strokes in people with diabetes by 35% deaths from any cause by 21%

When talking about GLP-1 agonists, they bind to the GLP receptors to trigger the effects like the naturally occurring GLP-1 hormone

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27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication