What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work
But one of the biggest questions patients ask early in their journey is simple: How long do you take GLP-1 for weight loss
Specifically for semaglutide, patients were found to regain 66% of their lost weight 1 year after stopping Wegovy
Red flag symptoms requiring urgent evaluation include sudden severe pelvic/abdominal pain, fever, heavy bleeding with syncope, positive pregnancy test (to rule out ectopic pregnancy), or signs of bowel or urinary obstruction
Total weekly drug exposure stays the same