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Both SGLT2-i and valsartan/sacubitril reduce Na+ reabsorption in the proximal tubule and therefore stimulate TGF

As you move into maintenance, we usually reduce that to every two weeks or monthly, adjusted to how you respond and your providers guidance

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This normalization can result in improved sleep quality, mood stabilization, and enhanced cognitive function Anisimov et al., Neuroendocrinol Lett , 2001