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Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25Nrf2 pathway

38 (1), e23543

That benefit is especially important for mature skin, as dryness and dullness can become more pronounced with age

Patients and clinicians should nonetheless remain alert to this possibility, particularly given the substantial weight loss retatrutide has produced in phase 2 trial settings (see the New England Journal of Medicine , 2023)