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The principle lipase implicated in TBI is cytoplasmic phospholipase A2 (cPLA2), which is upregulated after in vivo and in vitro experimental TBI and preferentially cleaves arachidonic acid as an essential part of enzymatic lipid peroxidation and inflammatory signal transduction [82]
Cadmium exposure dysregulates purine metabolism and homeostasis across the gut-liver axis in a mouse model
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