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Some remarkable results are the decline of PSA after combination of metformin with bicalutamide after 8 weeks (42.1% bicalutamide + metformin vs 11.1% only bicalutamide) in PC patients with overweight (ClinicalTrial.gov ID NCT02614859), and with castration after 7 months (placebo PSA 58.2 ng/mL vs metformin PSA 8.36 ng/mL, ClinicalTrial.gov ID NCT01620593, [191]), and its detection in the prostatic tissue after consumption for 12 weeks, but without changes in tumor progression markers (ClinicalTrials.gov ID NCT01433913, [192])

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If no improvement occurs after 3-4 weeks at appropriate doses, product quality may be an issue, or the condition may not respond to this approach

We do not endorse supplement use or any product or supplement vendor, and all discussion here is for scientific interest

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