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Similar to GIP, the stimulatory effects of GLP-1 on insulin expression and secretion were observed in the presence of high (450 mg/dL) but not normal (99 mg/dL) concentrations of glucose in the cultured cells, indicating the glucose-dependent insulinotropic effect of GLP-1 (117)
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In clinical studies, people taking injectable semaglutide (Wegovy) lost an average of about 7% of their body weight after 3 months at higher doses
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Over the years, disulfide-containing compounds (-SS-) have been extensively explored in the development of GSH-sensitive drug delivery systems (DDSs) [52]
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