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some may trial high-dose oral with close monitoring (NHS)

If your B12 levels are already solid, the impact might be minimal

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Studies have shown that supplementing cobalamin in deficient cats experiencing gastrointestinal disease, like vomiting and diarrhea, has led to a significant improvement in GI signs, as well as weight gain

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007