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When taken orally, peptides are notoriously unstable and difficult to deliver to the target location, meaning it would be very unlikely that it would reach the nucleus pulposus directly

GHRP-6 also binds to the ectodomain of CD36, a receptor involved in fatty acid uptake, angiogenesis, and immune function

The treatment groups outperformed placebo by 5.5 (Group A) to 7.4 (Group B), providing clear evidence that the improvement was caused by the active ingredients, not the placebo effect

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While semaglutide remains a gold standard for many, the addition of the GIP receptor activation in Mounjaro is a primary reason why some patients or providers prefer it, especially if weight loss is the main goal or if blood sugar levels are particularly difficult to manage