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The phase 1b, 16-week, multiple-dose ascending trial (NCT05613387) showed a mean body weight reduction of 4.8%, 8.6% and 8.3% at OW doses of up to 2.4 mg, 4.8 mg and 9.0 mg, respectively [116]
That is, a tonic challenge produces a steady-state change in the regulated variable that is determined by the strength of the challenge relative to the strength of the feedback gain
While use exclusively for weight management will still not be covered, anti-obesity medications that have FDA approval for an additional medically accepted indication, such as reducing the risk of major cardiovascular events, can be covered when used to treat that condition
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