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15,23 Tyr 1 and Ile 7 are crucial for the selective activation of GIPR by GIP
8 (1), 5458 (2021) A
Fatty acids also have to compete with glucose for transport into the mitochondria
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New ligands are needed for the targets of known structure, wherein the potential compounds are screened for their adequate efficacy against a target of interest, and also the therapeutic dosage approval is possible by analyzing the ADMET properties to be able to abide by the Lipinski rule and investigate the drug likeliness of the compound (108, 109)
2.2.2 Intervention(s) Any GLP-1 receptor agonist that has been approved for the treatment of type 2 diabetes was used as the intervention of interest
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