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PMID: 40573323

The differences described here are patterns in anecdotal reports and animal data, not conclusions from clinical pharmacology

B12 is crucial for the production of red blood cells and the maintenance of healthy nerve cells

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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output