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Consequently, there is an urgent need for highly effective emerging therapeutic modalities
Dalmasso G et al
It is central to the redox reactions that power cellular energy metabolism
ACSL4 acylates AA, LPCAT3 catalyzes the acylated AA into membrane PLs, and then lipoxygenases (LOXs) catalyze PUFA PLs, producing native lipid peroxidation (41) (Figure 1)
The novel finding of the present study is that l-Carnitine protects RTCs from PFOS-mediated apoptosis by inhibiting the induction of ROS, pERK1/2, and IRE1 and then causing autophagy activation
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