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In severe trauma, high plasma mtDNA predicted later development of AKI (202)

42 In the STEP 1 study, participants who achieved a mean weight loss of 10.6% after 20 weeks of semaglutide were rerandomized in STEP 4 to either continue semaglutide or switch to placebo for an additional 48 weeks

Detailed analysis included examining messenger RNA (mRNA) levels for enzymes potentially involved in the liver's urea cycle