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S., Fu, H

These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts

Proliferation (log 2 doublings, 5 days) of indicated GPX4-deficient cell lines in vitro either untreated or supplemented with cholesterol (5 g/mL), combined native LDL and HDL (50 g/mL), combined tristearin-reconstituted LDL and HDL (rLDL+rHDL, 50 g/mL), or Fer-1 (1 M)

A target of 64-80 ounces of fluid daily is appropriate for most patients (with adjustments for heart failure or kidney disease), with modifications based on activity level, climate, and gastrointestinal losses

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