an oral melanotic macule on lower lip Mucosal melanocytic macules Any information on dark spots – oral melanotic macule symptoms Differential

Davies-Jenkins, View ORCID ProfileHelge J

Since CagriSema contains semaglutide, switching from Wegovy to CagriSema means adding cagrilintide to existing therapy

Acknowledgements The authors acknowledge Matthew Wither for generating the untargeted liver metabolomics data

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

Research question and search strategy The research question was What are the mechanisms of action of carnitine (s) that attenuated or counteracted the dioxin(s)-inducing fatty liver, to be a reason for using it in the management of MASLD/MDAFLD/NAFLD/NASH?