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Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins such as plasma proteins, hormones, neuropeptides, and growth factors 331
We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says
They mimic a natural gut hormone that signals fullness, slows stomach emptying, and helps the body use insulin more efficiently
Because they are amino acid sequences, the body can usually break them down and clear them efficiently
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