Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose approximately two and four times the clinical dose, respectively, based on measured drug exposure (AUC)
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These thresholds were chosen to ensure consistency in patient selection and comparability with previous reports
Consequent endothelium damage results in increased permeability of the endothelium due to disruption of cellcell junction (18)
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