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Maselli DB, Lee D, Bi D, Jirapinyo P, Thompson CC, Donnangelo LL et al (2024) Safe continuation of glucagon-like peptide 1 receptor agonists at endoscopy: a case series of 57 adults undergoing endoscopic sleeve gastroplasty
But usually, a series of treatments provide the most noticeable benefits
Standard recommendations already favor GLP-1 receptor agonists for T2DM patients with prior atherosclerotic cardiovascular disease and SGLT-2 inhibitors for those with chronic kidney disease or heart failure
More serious risks include pancreatitis, gallbladder disease, and potential thyroid concerns (GLP-1 medications carry a boxed warning about thyroid C-cell tumors based on animal studies)
Examples include: Medical contraindications to GLP-1 therapy Lack of clinical supervision No structured plan for muscle preservation Hormonal status not yet evaluated Reducing the dose does not remove contraindications or eliminate underlying medical risks
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